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What performance and caching considerations become especially important when developing a WordPress plugin that will run on a high traffic website?

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Answer

A WordPress plugin running on a high traffic website needs particular attention paid to performance, since a poorly optimized plugin, such as one that runs an expensive, unnecessary database query on every single page load regardless of whether that specific page actually needs that data, can noticeably slow down an entire site, and important considerations include using the WordPress Transients API or an external caching layer like Redis to cache the results of expensive operations, being careful about exactly when and how often a plugin's hooked functions actually execute, and avoiding loading unnecessary CSS or JavaScript files on pages where a plugin's specific functionality is not actually being used at all.
$data = get_transient('expensive_report_data');
if ($data === false) {
    $data = generate_expensive_report();
    set_transient('expensive_report_data', $data, HOUR_IN_SECONDS);
}
Real-world example A WordPress analytics plugin caches the results of an expensive report generation process using the Transients API for one hour, dramatically reducing server load on a high traffic site compared to regenerating that same expensive report from scratch on every single page load.

Common follow-ups: How does the WordPress Transients API differ from directly using an external caching system like Redis?;What tools are available for actually profiling and measuring where a WordPress plugin's performance bottlenecks genuinely lie?